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Published on: April 13, 2018
Ultrasound enhanced thrombolysis in experimental retinal vein occlusion in the rabbit
J Larsson1, J Carlson, S B Olsson
1Department of Ophthalmology, Lund University Hospital, Sweden.
Aims:
To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound.
Methods:
53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours.
Results:
In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21% of the vessels were open. In the group that was treated with streptokinase (25,000 IU/kg) and ultrasound, 64% of the vessels were open. The difference between groups 2 and 3 is statistically significant (p = 0.011)
Conclusion:
Adding pulsed low energy ultrasound makes it possible to lower the dose of streptokinase while maintaining a good thrombolytic effect.
