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Changes in head and neck tumor hypoxic fraction during split-course radiochemotherapy
R Jund1, H J Feldmann, B Wollenberg
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Munich, Klinikum Grosshadern, Germany.
The Annals of Otology, Rhinology, and Laryngology
|February 4, 1999
Summary
This study investigated tumor oxygen levels in head and neck cancer patients undergoing radiochemotherapy. Results show significant variability in oxygenation, with a trend towards reduced hypoxia after a treatment break.
Area of Science:
- Oncology
- Medical Physics
- Radiotherapy
Background:
- Tumor hypoxia is a known factor influencing radiotherapy resistance.
- Understanding oxygen distribution is crucial for optimizing cancer treatment strategies.
Purpose of the Study:
- To explore intratumoral oxygen distribution patterns in head and neck squamous cell carcinoma during primary radiochemotherapy.
- To assess changes in tissue oxygen tension (pO2) and hypoxic fraction over the course of treatment.
Main Methods:
- Intratumoral pO2 measurements using polarographic needle electrodes and histography.
- Evaluation of patients (n=15) with positive nodes before, during, and after radiochemotherapy, including a 2-week respite.
- Definition of hypoxic fraction based on lowest pO2 classes (0 and 5 mm Hg).
Main Results:
- Significant initial variability in tumor pO2 and hypoxic fraction (0-61%).
- Changes in mean pO2 observed by the end of treatment (4 increased, 7 decreased).
- A notable decrease in the hypoxic fraction occurred in 9 tumors after the 2-week respite.
Conclusions:
- Human head and neck tumors exhibit widespread tissue oxygenation with significant hypoxic zones.
- Tumor oxygenation is dynamic and highly variable during radiochemotherapy.
- A potential reduction in tumor hypoxia following a treatment pause warrants further investigation.