Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human annexin 31 genetic mapping and origin

R O Morgan1, D W Bell, J R Testa

  • 1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, E-33006, Oviedo, Spain. mpff@dwarf1.quimica.uniovi.es

Gene
|February 5, 1999
PubMed
Summary

Novel human annexin 31 (ANX31) gene maps to chromosome 1q21. Phylogenetic analysis reveals annexin 2 as its closest homologue, with the subfamily forming 500-600 million years ago.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applied and environmental microbiology·2018
Same author

Green alder (Alnus viridis) encroachment shapes microbial communities in subalpine soils and impacts its bacterial or fungal symbionts differently.

Environmental microbiology·2017
Same author

Host-Feeding Sources and Infection With Trypanosoma cruzi of Triatoma infestans and Triatoma eratyrusiformis (Hemiptera: Reduviidae) From the Calchaqui Valleys in Northwestern Argentina.

Journal of medical entomology·2016
Same author

Comparison of Modern Methods for Analyzing Repeated Measures Data With Missing Values.

Multivariate behavioral research·2016
Same author

Impact of timing of adjuvant chemotherapy initiation and completion after surgery on racial disparities in survival among women with breast cancer.

Medical oncology (Northwood, London, England)·2013
Same author

Murine mantle cell lymphoma model cell line.

Leukemia·2012

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Annexins are a family of calcium-dependent phospholipid-binding proteins involved in various cellular processes.
  • The genetic relationships and evolutionary history of annexins are not fully elucidated.
  • A novel human annexin, designated annexin 31 (ANX31), has been identified.

Purpose of the Study:

  • To determine the chromosomal location of the novel human ANX31 gene.
  • To compare the structure and evolutionary relationships of ANX31 with other known annexins.
  • To understand the evolutionary origin and divergence of the ANX31 subfamily.

Main Methods:

  • Fluorescence in situ hybridization (FISH) for chromosomal mapping of the ANX31 gene locus.
  • Protein homology analysis using expressed sequence tags (ESTs) to identify the closest homologue.

Related Experiment Videos

  • Maximum likelihood phylogenetic analysis to infer evolutionary relationships and divergence times.

    • Main Results:

    • The ANX31 gene was mapped to human chromosome 1q21, near the epidermal differentiation complex and S100A gene cluster.
    • Annexin 2 was identified as the closest extant homologue of ANX31.
    • Phylogenetic analysis indicated the ANX31 subfamily diverged from annexin 1 approximately 500-600 million years ago and has undergone rapid evolution, particularly in calcium-binding sites.

    Conclusions:

    • Human ANX31 is a distinct gene located on chromosome 1q21, separate from other human annexin genes.
    • Annexin 31 represents a relatively ancient subfamily, with annexin 2 as its closest relative.
    • The ANX31 subfamily shows significant evolutionary divergence, highlighting adaptive changes in critical functional regions.