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Plasma phenylethanolamine in hepatic encephalopathy

C Cangiano, F Rossi-Fanelli, A Bozzi

    European Journal of Clinical Investigation
    |June 1, 1978
    PubMed
    Summary

    Plasma phenylethanolamine levels are elevated in patients with liver cirrhosis and hepatic encephalopathy. This finding supports the false neurotransmitter hypothesis, suggesting phenylethanolamine

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    Area of Science:

    • Neuroscience
    • Hepatology
    • Biochemistry

    Background:

    • Hepatic encephalopathy (HE) is a complex neurological complication of liver disease.
    • The role of specific neuroamines, beyond octopamine, in HE pathogenesis is under investigation.

    Purpose of the Study:

    • To investigate the role of phenylethanolamine in the pathogenesis of hepatic encephalopathy.
    • To quantify plasma phenylethanolamine levels in patients with liver cirrhosis and HE.

    Main Methods:

    • Plasma phenylethanolamine was measured using a radioenzymatic assay.
    • The study included 26 patients with biopsy-proven cirrhosis (with or without HE) and 7 healthy controls.

    Main Results:

    • Plasma phenylethanolamine levels showed a statistically significant correlation with the presence of liver cirrhosis.

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  • Elevated phenylethanolamine levels were associated with severe coma in patients with hepatic encephalopathy.

    • Conclusions:

    • The findings support the false neurotransmitter hypothesis of hepatic encephalopathy.
    • Phenylethanolamine may play a role in the neurological dysfunction observed in liver cirrhosis.