Fos expression during the critical period in visual cortex: differences between normal and dark reared cats

The present study tested further the notion that immediate early gene expression is involved in neuronal plasticity during the critical period of visual cortex (VC) by comparing Fos induction in normal and dark reared (DR) cats. Western blots indicated that the level of induced Fos expression was higher in normal than DR cat VC at 5 weeks of age, comparable at 10 weeks, and higher in DR than normal cat VC at 20 weeks. Immunohistochemistry indicated that at 5 weeks Fos was induced in cells of all VC layers in both rearing conditions, but to a greater extent in normal than DR cats. At 20 weeks, Fos was largely restricted to cells above and below layer IV in both rearing conditions, but was induced to a greater extent in DR than normal cats. Thus, dark rearing appears to have very similar effects on Fos expression as it has on neuronal plasticity during the postnatal critical period.