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Related Experiment Videos

Human coagulation abnormalities during acute exposure to hypobaric hypoxia

J T Maher, P H Levine, A Cymerman

    Journal of Applied Physiology
    |November 1, 1976
    PubMed
    Summary

    High-altitude exposure in healthy men did not alter platelet function but caused significant changes in coagulation. Partial thromboplastin time shortened, and fibrinogen/factor VIII levels dropped, indicating a potential coagulopathy.

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    Area of Science:

    • Physiology
    • Hematology
    • Altitude Medicine

    Background:

    • High-altitude exposure is known to affect various physiological systems.
    • Understanding the impact on coagulation is crucial for assessing health risks.

    Purpose of the Study:

    • To investigate the effects of simulated high altitude on coagulation parameters in healthy young men.
    • To assess changes in platelet function and other coagulation factors.

    Main Methods:

    • Coagulation studies were performed on eight healthy men at sea level and after 1, 24, and 48 hours at simulated 4,400 m altitude.
    • Evaluated platelet aggregation, 2,3-diphosphoglycerate, platelet count, factor 3 availability, lipid peroxide formation, prothrombin time, thrombin time, partial thromboplastin time, fibrinogen, factor VIII, and fibrin degradation products.

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    Main Results:

    • Platelet aggregation remained unchanged.
    • Mean 2,3-diphosphoglycerate levels increased significantly after 24 hours.
    • Partial thromboplastin time was significantly shortened at 1 and 24 hours.
    • Fibrinogen and factor VIII levels decreased after 1 hour but returned to baseline by 24 hours.
    • Fibrin degradation products were transiently detected in some subjects.

    Conclusions:

    • Short-term simulated high-altitude exposure did not impair normal platelet function.
    • Evidence suggests a transient coagulopathy, characterized by shortened partial thromboplastin time and altered fibrinogen/factor VIII levels.
    • Further research is needed to fully elucidate the hemostatic changes at high altitude.