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[Synopsis of modern tumor therapy with molecular biology methods]
1Klinik für Allgemeine Chirurgie und Thoraxchirurgie, CAU, Kiel.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|February 5, 1999
Abstract:
The therapy of gastrointestinal cancer is currently based on the surgical removal of the primary tumor or the metastases, respectively. A major improvement of the five year survival rate or an effective cure from advanced tumors will mainly depend on adjuvant therapeutic concepts even after surgical R0-resection. Such concepts can be developed nowadays with major expectations for success based on our advanced molecular biological knowledge on (i) increased proliferation, (ii) reduced apoptosis rate, (iii) the dissemination and (iv) the mechanisms of invasive growth of malignant cells.