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[Geographical differences of thyroid carcinoma and basic molecular principles]
P E Goretzki1, J Witte, C Dotzenrath
1Klinik für Allgemein- und Unfallchirurgie, Heinrich-Heine Universität Düsseldorf.
Abstract:
Geographical differences have been demonstrated for the cancer incidence and histology of differentiated thyroid cancer. Iodine intake and specific external noxes, such as nitrosamine ingestion or external radiation are important factors. It is still questionable whether histologically identical differentiated thyroid cancers are prognostically different in low and rich iodine areas. Despite increased knowledge of molecular and genetic changes in differentiated cancer, the present therapy is primarily related to patient age, tumor stage and histology.