Related Experiment Videos
[Induction of early endotoxin tolerance with atoxic endotoxin--a new method for preventing sepsis syndrome]
K H Staubach1, H Weber, H Brade
1Klinik für Chirurgie, Medizinische Universität zu Lübeck.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|February 5, 1999
Abstract:
The induction of early-phase endotoxin tolerance in a procine endotoxin shock model by atoxic LPS from Rhodobacter sphaeroides led to a significant extension of the survival time (p < 0.0179). The protective effect of the non-specific tolerant state also led to an enhancement of cardiorespiratory parameters during the continuous endotoxin challenge. Non-specific stimulation of host defense mechanisms with atoxic endotoxin as prophylactic agent in surgical patients at risk may prove to be beneficial in the future.