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Updated: Oct 14, 2026

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
[Combination of profundaplasty and pharmacotherapy in stage III/IV peripheral arterial occlusive disease]
1Abteilung für Gefässchirurgie, Kurhessisches Diakonissenhaus, Kassel.
Abstract:
This prospective randomized study shows that adjuvant 3-week i.v. PGE1 treatment substantially improves the short-term results in patients undergoing profundaplasty. Compared with placebo, PGE1 approximately doubles the number of patients returning from stage III/IV to stage IIb of PAOD. Five years after surgery, the outcome with respect to limb salvage and patient survival rate was significantly better in patients additionally treated with PGE1.
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