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[Protein expression of hMSH2 and hMLH1 in HNPCC: evaluation of a prescreening method]
S Vossen1, G Möslein, M Katzer
1Abteilung für Allgemeine und Unfallchirurgie, Heinrich-Heine-Universität, Düsseldorf.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|February 5, 1999
Abstract:
We show that immunohistochemistry for hMSH2 and hMLH1 is an easy and reproducible routine procedure. The interpretation of the staining results is unequivocal and investigator-independent. It is now necessary to validate the specificity and sensitivity of the method in a multicenter study with tumors of known mutations. As a consequence perhaps MIN testing may be replaced by immunohistochemistry as a first-line pretesting for HNPCC, reducing cost and time required.