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Related Experiment Videos

Lipoatrophy induced by recombinant human insulin injection

S Murao1, K Hirata, T Ishida

  • 1Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime.

Internal Medicine (Tokyo, Japan)
|February 5, 1999
PubMed
Summary

A rare case of subcutaneous fat atrophy occurred in a patient treated with recombinant human insulin. Switching insulin types and injection sites resolved the lipoatrophy, suggesting an immunological reaction.

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Area of Science:

  • Endocrinology
  • Dermatology
  • Immunology

Background:

  • Recombinant human insulin is widely used for diabetes management.
  • Insulin-induced lipoatrophy, a known complication, is now rare with modern insulin formulations.

Observation:

  • A 79-year-old male developed subcutaneous fat atrophy at insulin injection sites after 16 months of recombinant human insulin therapy.
  • Skin biopsy confirmed inflammatory changes and adipocyte atrophy.

Findings:

  • The patient's lipoatrophy resolved after changing the insulin type and injection site.
  • This suggests an immunological reaction to the specific insulin product may have caused the lipoatrophy.

Implications:

  • This case highlights that even rare complications like insulin-induced lipoatrophy can occur with modern insulins.

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  • Monitoring for injection site reactions remains important in patients using insulin therapy.