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Effects of antithrombin on Binswanger's disease with antiphospholipid antibody syndrome
I Akiguchi1, H Tomimoto, M Kinoshita
1Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Neurology
|February 5, 1999
Insights
This study details a family with Binswanger
Area of Science:
- Neurology
- Rheumatology
- Hematology
Background:
- Binswanger's disease (BD) is a form of subcortical dementia.
- Antiphospholipid antibody syndrome (APAS) is an autoimmune disorder causing thrombotic events.
Observation:
- A family presented with co-occurring Binswanger's disease and antiphospholipid antibody syndrome.
- One patient exhibited lupus anticoagulant and elevated hemostatic markers.
Findings:
- The co-occurrence of BD and APAS in this family is unique.
- The patient showed clinical and biological improvements following antithrombin treatment.
Implications:
- This case highlights a potential link between BD and APAS in a familial context.
- Antithrombin therapy may offer benefits for patients with this specific familial APAS phenotype.
Abstract:
The authors present a family with Binswanger's disease (BD) and antiphospholipid antibody syndrome (APAS). In one patient from this family, lupus anticoagulant and high levels of hemostatic markers were detected. The presence of BD and the clinicobiological improvements observed after antithrombin treatment in this patient are peculiar to this familial case of APAS.