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Bilateral optic neuropathy with IgGkappa multiple myeloma improved after myeloablative chemotherapy
F S Lieberman1, J Odel, J Hirsh
1Department of Neurology, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, NY, USA. frank_lieberman@smtplink.mssm.edu
Neurology
|February 5, 1999
Abstract:
A 49-year-old woman with immunoglobulin GK multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas. Funduscopic and electrophysiologic studies indicated bilateral optic neuropathy. The immunoglobulin G fraction of the patient's serum reacted with retinal ganglionic cells in bovine retina. The visual abnormalities remitted after myeloablative chemotherapy and disappearance of the paraprotein.