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Protein phosphatase 2A: who shall regulate the regulator?
1INSERM U244, Biochimie des Regulations Cellulaires Endocrines, Departement de Biologie Moleculaire et Structurale, Commissariat a l'Energie Atomique, CEA/Grenoble, France. yves.goldberg@ujf-grenoble.fr
Biochemical Pharmacology
|February 5, 1999
Summary
Protein phosphatase 2A (PP2A) regulation involves protein-protein interactions. Diverse subunits and viral proteins modulate PP2A activity, impacting cell growth and signaling pathways.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Protein phosphatases counteract protein kinases in cell signaling.
- Protein phosphatase 2A (PP2A) is crucial for regulating cell growth and division.
- Understanding PP2A regulation is key to comprehending cellular processes.
Purpose of the Study:
- To review the role of protein-protein interactions in regulating PP2A.
- To explore how regulatory subunits, inhibitors, and viral proteins affect PP2A.
- To discuss novel PP2A partners and their roles in signal transduction.
Main Methods:
- Literature review of studies on PP2A regulation.
- Analysis of protein-protein interactions involving PP2A.
- Examination of PP2A's role in signal transduction pathways.
Main Results:
- PP2A activity, specificity, and localization are controlled by diverse regulatory subunits and inhibitors.
- DNA tumor viruses disrupt PP2A function by competing for regulatory subunits, affecting signaling pathways like MAPK.
- PP2A interacts with novel partners such as Tap42/alpha4 and CK2alpha, influencing mRNA translation and mitogenic signaling.
Conclusions:
- Protein-protein interactions are critical for PP2A regulation.
- Dysregulation of PP2A by viral proteins can lead to pathological changes.
- Novel PP2A interactions highlight its complex role in intracellular signaling networks.