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Related Experiment Videos

Lactic acid does not directly activate hypothalamic-pituitary corticotroph function

J S Petrides1, P A Deuster, G P Mueller

  • 1Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|February 5, 1999
PubMed
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Lactic acid does not directly impact the pituitary gland

Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Neuroscience

Background:

  • The hypothalamic-pituitary-adrenal (HPA) axis is crucial for stress response.
  • Metabolic products during exercise, like lactic acid, may influence HPA axis regulation.
  • The direct role of lactic acid on pituitary function remains unclear.

Purpose of the Study:

  • To investigate the direct effect of lactic acid on hypothalamic-pituitary function.
  • To determine if lactic acid influences beta-endorphin secretion from corticotroph cells.
  • To explore lactate's interaction with pituitary secretagogues.

Main Methods:

  • Utilized AtT-20 mouse corticotroph tumor cells and primary rat anterior pituitary cultures.
  • Administered physiological levels of lactate acutely and chronically.

Related Experiment Videos

  • Measured beta-endorphin release with and without co-stimulation by CRH, AVP, norepinephrine, and epinephrine.
  • Examined lactate's effect on CRH release from rat hypothalamic explants.

    • Main Results:

    • Lactic acid did not alter basal or stimulated beta-endorphin release from pituitary cells.
    • Lactate did not modify the effects of CRH, AVP, norepinephrine, or epinephrine on beta-endorphin secretion.
    • Lactate significantly reduced spontaneous CRH release from hypothalamic explants.

    Conclusions:

    • Physiological lactate concentrations do not directly affect pituitary corticotroph secretion.
    • Lactate may inhibit CRH release, potentially aiding post-exercise HPA axis recovery.
    • Lactic acid does not appear to directly mediate HPA axis activation during strenuous exercise.