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Peritoneal serous papillary carcinoma: radiological appearance
T Furukawa1, J Ueda, S Takahashi
1Department of Radiology, Sumitomo Hospital, 5-2-2 Nakanoshima, Kita-ku, Osaka 530-0005, Japan.
Abdominal Imaging
|February 6, 1999
Summary
Peritoneal serous papillary carcinoma (PSPC) presents with massive ascites and omental tumors. High serum CA125 levels may aid in diagnosing PSPC, justifying surgery when characteristic imaging is present.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- This study describes the radiological appearance of peritoneal serous papillary carcinoma (PSPC).
- PSPC is a rare malignancy that can mimic other peritoneal diseases.
Observation:
- Computed tomography revealed massive ascites and omental tumors in all three female patients (aged 44-71).
- Radiological exams excluded primary gastrointestinal or genital tumors.
- Histopathology confirmed large omental tumors involving the transverse colon, with minimal ovarian involvement.
Findings:
- Serum CA125 was markedly elevated in all patients.
- Immunohistochemical staining confirmed CA125 positivity in tumor cell cytoplasm.
- Radiological findings alone were insufficient for definitive PSPC diagnosis due to similarities with metastatic carcinomatosis and mesothelioma.
Implications:
- Elevated serum CA125 levels can assist in the diagnosis of PSPC.
- Promising treatment responses suggest exploratory laparotomy is warranted for characteristic radiological findings and high CA125 levels.