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Thermal biosensors in biotechnology

F Lammers¹, T Scheper

¹Institute for Technical Chemistry, Hannover, Germany. frank.lammers@hmrag.com

Advances in Biochemical Engineering/Biotechnology

|February 6, 1999

Summary

Enzyme thermistor devices offer continuous monitoring of enzymatic processes. These biosensors are versatile, applied in biotransformation analysis, immunoassays, and medical diagnostics like hemodialysis monitoring.

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Area of Science:

Biotechnology
Analytical Chemistry
Biosensor Technology

Background:

Enzymatic processes require precise and continuous monitoring for optimal control and analysis.
Traditional monitoring methods can be time-consuming and may not provide real-time data.
Enzyme thermistor devices offer a promising alternative for sensitive and rapid detection.

Purpose of the Study:

To describe the application of enzyme thermistor devices for continuous monitoring of enzymatic processes.
To present and discuss various hardware concepts for enzyme thermistor devices.
To demonstrate the utility of these biosensors in diverse analytical and diagnostic applications.

Main Methods:

Development and application of enzyme thermistor devices with different hardware concepts.
Utilizing thermal detection principles for enzymatic activity and binding events.
Integration of biosensors into analytical and process monitoring systems.

Main Results:

Demonstrated successful continuous monitoring of enzymatic processes.
Analyzed enantiomeric excess in biotransformation and performed thermal immunoassays.
Applied biosensors for monitoring L-ornithine production and in hemodialysis monitoring.

Conclusions:

Enzyme thermistor devices are effective tools for real-time monitoring of enzymatic reactions.
These thermal biosensors show broad applicability across various biotechnological and biomedical fields.
The technology provides a valuable platform for process control, quality assurance, and diagnostics.

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