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Synthesis of photoaffinity label analogues of alpha-tocopherol
1Department of Chemistry, Brock University, St. Catharines, Ontario, Canada.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
Photoaffinity analogues of alpha-tocopherol have been synthesized that incorporate the photosensitive 4-azido-2,3,5,6-tetrafluorobenzyloxy group at the terminus of unbranched analogues of the naturally occurring phytyl side chain. An intermediate from these syntheses has also been used to generate a supported ligand for bioaffinity chromatography of alpha-tocopherol binding proteins.