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Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense
T Fujioka1, M Yamamoto, Y Kashiwada
1Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structures were established by spectroscopic examinations. Compounds 1, 2, and 3 were cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.37 microM, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 microM, respectively.