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Inhibition stereochemistry of hydroxamate inhibitors for thermolysin
1Center for Biofunctional Molecules, Pohang University of Science and Technology, Korea.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
N-Acyl-N-hydroxy-beta-amino acid derivatives were prepared and tested as inhibitors for thermolysin to find that these inhibitors show the L-stereospecificity in contrast to the corresponding hydroxamates prepared from alpha-amino acid, which exhibit the D-stereochemistry. N-Formyl-N-hydroxy-beta-L-Phe-NHMe is the most potent inhibitor having the Ki value of 1.66 microM.