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Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors
C Terán1, L Santana, E Uriarte
1Department of Physical Chemistry and Organic Chemistry, University of Vigo, Spain.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3.