The discovery of orally available thrombin inhibitors: studies towards the optimisation of CGH1668
Related Experiment Video
Updated: Oct 25, 2026

08:01
The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
The chemical optimisation of CGH1668 1 is described employing an in vivo model of absorption to determine the influence on bioavailability of single point modifications to five key molecular templates. The discovery of an orally bioavailable and selective thrombin inhibitor, 24, highlights the utility of this approach.

