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13:47
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
Published on: June 23, 2011
Design and synthesis of novel conformationally restricted HIV protease inhibitors
F G Salituro1, C T Baker, J J Court
1Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
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