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N6-(5,6-epoxynorbornyl)adenosine analogs as A1 adenosine agonists
D M Wright1, S P Baker, S G Stewart
1School of Biological & Chemical Sciences, Deakin University, Geelong, Vic., Australia.
Bioorganic & Medicinal Chemistry Letters
|February 6, 1999
Abstract:
A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6 position have been synthesised and evaluated as A1-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50 = 1.1 nM).