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Differential activity of rosiglitazone enantiomers at PPAR gamma

D J Parks¹, N C Tomkinson, M S Villeneuve

¹Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA.

Bioorganic & Medicinal Chemistry Letters

|February 6, 1999

Abstract:

Analysis of the enantiomers of rosiglitazone in a PPAR gamma binding assay suggests that the (S)-(-)-isomer is responsible for the antidiabetic activity.

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