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Monozygotic twinning associated with mechanical assisted hatching

A Hershlag1, T Paine, G W Cooper

  • 1Department of Obstetrics and Gynecology, North Shore University Hospital-New York University Medical College, Manhassett 11030, USA.

Fertility and Sterility
|February 6, 1999
PubMed
Summary

Mechanical assisted hatching increases pregnancy rates in assisted reproductive technology (ART) cycles. However, it also significantly raises the risk of multiple pregnancies and monozygotic twins.

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Area of Science:

  • Reproductive Medicine
  • Assisted Reproductive Technology (ART)
  • Embryology

Background:

  • Assisted hatching is a technique used in assisted reproductive technology (ART) to improve embryo implantation.
  • The impact of mechanical assisted hatching on pregnancy outcomes requires further clarification.

Purpose of the Study:

  • To evaluate the effect of mechanical assisted hatching on pregnancy rates.
  • To assess the influence of assisted hatching on multiple gestation and twinning rates.

Main Methods:

  • Retrospective comparative analysis of assisted reproductive technology (ART) cycles.
  • Comparison between cycles with and without mechanical assisted hatching.
  • Data collected from a hospital-based ART program.

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Main Results:

  • Clinical pregnancy rate per embryo transfer (ET) increased from 25.2% to 37.1% with assisted hatching.
  • Multiple pregnancy rate per ET rose from 6.8% to 13.1% following assisted hatching.
  • A notable increase in monozygotic twinning was observed in the assisted hatching group (1.2% per ET).

Conclusions:

  • Mechanical assisted hatching enhances pregnancy rates in ART.
  • The procedure is associated with a higher incidence of multiple gestations, including high-order multiples.
  • There is a significant risk of monozygotic twinning with mechanical assisted hatching.