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Autonomic neuropathy associated with sicca complex

R A Wright1, I A Grant, P A Low

  • 1Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Journal of the Autonomic Nervous System
|February 6, 1999
PubMed
Summary
This summary is machine-generated.

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Sicca complex frequently involves autonomic dysfunction, though severe cases are rare. Most patients experience mild or no symptoms, with varied autonomic and somatic neuropathy patterns observed.

Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Sicca complex, often associated with autoimmune conditions, can manifest with neurological complications.
  • Peripheral neuropathic symptoms are a common presentation, prompting investigation into autonomic nervous system involvement.

Observation:

  • A retrospective study of 52 sicca complex patients revealed significant autonomic involvement in 87% via autonomic reflex screening (ARS).
  • Mixed patterns of autonomic dysfunction (sudomotor, cardiovagal, adrenergic) were observed in 58% of patients.
  • While autonomic neuropathy coexisted with various somatic neuropathies, no clear subtype relationship emerged.

Findings:

  • A broad spectrum of autonomic dysfunction exists in sicca complex, ranging from asymptomatic to severe panautonomic dysfunction.
  • Severe autonomic involvement is infrequent; most patients exhibit mild or subclinical disease.
Keywords:
Non-programmatic

Related Experiment Videos

  • No predominant autonomic dysfunction patterns or clear links to specific somatic neuropathies were identified.
  • Extraglandular manifestations and specific serological markers (ENA, SS-A, SS-B) were uncommon in this cohort.

    • Implications:

    • Autonomic reflex screening is valuable for detecting diverse autonomic involvement in sicca complex patients.
    • The findings underscore the heterogeneity of neurological involvement in sicca complex.
    • Further research may clarify the pathogenesis and clinical significance of autonomic neuropathy in sicca complex.