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Insulin coma therapy: decrease of plasma tryptophan in man

P Baumann, J MGaillard

    Journal of Neural Transmission
    |January 1, 1976
    PubMed
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    Insulin therapy decreased plasma tryptophan and tyrosine levels in patients. Glucose administration reversed this effect, suggesting insulin may enhance brain tryptophan uptake and serotonin synthesis.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Endocrinology

    Background:

    • Insulin coma therapy was historically used for psychiatric conditions.
    • The role of insulin in amino acid metabolism and neurotransmitter synthesis is not fully understood.

    Purpose of the Study:

    • To investigate the biochemical effects of insulin coma therapy on plasma amino acid levels.
    • To explore the potential influence of insulin on brain uptake of tryptophan and subsequent serotonin synthesis.

    Main Methods:

    • Biochemical analysis of plasma from two patients undergoing insulin coma therapy.
    • Measurement of free and total tryptophan, tyrosine, and non-esterified fatty acids (NEFA) before and after insulin and glucose administration.

    Main Results:

    Related Experiment Videos

    • Insulin injection decreased plasma free and total tryptophan and tyrosine.
    • Non-esterified fatty acids (NEFA) levels remained unchanged.
    • The ratio of tryptophan to tyrosine increased post-insulin.
    • Glucose administration following insulin increased free and total tryptophan.

    Conclusions:

    • Insulin administration appears to lower plasma tryptophan and tyrosine levels.
    • Insulin may facilitate the transport of tryptophan into the brain.
    • These findings support the hypothesis that insulin influences cerebral serotonin synthesis.