Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary fine structural changes in children with tissue hypoxia

M W Harrison, R S Connell, J R Campbell

    Journal of Pediatric Surgery
    |October 1, 1976
    PubMed
    Summary

    Four children showed lung ultrastructural changes linked to increased diffusion-perfusion of oxygen (DAVO2). These changes likely stem from microthrombi or microaggregates traveling to the lungs from under-oxygenated tissues.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risks and consequences of TB and its prevention in cost-utility analyses among immigrants: a systematic review.

    IJTLD open·2025
    Same author

    Association of smoking and alcohol use with rifampin-resistant TB treatment outcomes.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
    Same author

    WHO target product profiles for TB preventive treatment.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
    Same author

    Improving country-level modelling to support TB prevention and care.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
    Same author

    Interventions to reduce losses in the cascade of care for latent tuberculosis: a systematic review and meta-analysis.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020
    Same author

    Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers.

    Pharmaceutical research·2017

    Area of Science:

    • Pulmonary Medicine
    • Pediatric Pathology
    • Cardiopulmonary Physiology

    Background:

    • Pediatric lung diseases require detailed structural analysis.
    • Understanding the link between oxygenation and lung pathology is crucial.

    Purpose of the Study:

    • To investigate the ultrastructural changes in lung biopsies of children.
    • To correlate these changes with preoperative oxygenation levels.

    Main Methods:

    • Lung biopsy was performed on six children.
    • Histopathological and ultrastructural examination of lung tissue.
    • Preoperative arterial blood gas analysis to determine diffusion-perfusion of oxygen (DAVO2).

    Main Results:

    • Four out of six children exhibited increased DAVO2.

    Related Experiment Videos

  • These four children also showed significant ultrastructural abnormalities in their lung tissue.
  • No significant changes were noted in the other two children.

    • Conclusions:

    • Increased DAVO2 in children may indicate underlying lung pathology.
    • Lung ultrastructural changes appear to be associated with microthrombi or microaggregates.
    • Embolization from under-oxygenated tissues is a potential cause of these pulmonary changes.