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Related Experiment Videos

Effect of compression force and corn starch on tablet disintegration time

P M Hill

    Journal of Pharmaceutical Sciences
    |November 1, 1976
    PubMed
    Summary

    Tablet hardness usually increases disintegration time, but this study found the opposite. Increasing tablet hardness decreased disintegration time due to starch swelling, a key finding for pharmaceutical formulation.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Tablet disintegration is a critical factor in drug delivery.
    • Tablet hardness and disintegrant ratios can influence disintegration time.

    Purpose of the Study:

    • To investigate the unusual relationship between tablet hardness and disintegration time.
    • To explore the role of starch ratios in modifying this phenomenon.

    Main Methods:

    • Tablets were manufactured with varying starch disintegrant to starch paste ratios.
    • Tablets were compressed using eight distinct compression forces.

    Main Results:

    • An inverse correlation was observed: increased tablet hardness led to decreased disintegration time.
    • Altering starch ratios modified this observed disintegration pattern.

    Conclusions:

    • Starch swelling is identified as the primary mechanism responsible for the observed disintegration behavior.
    • This finding has implications for optimizing tablet formulations and manufacturing processes.

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