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Effect of diltiazem, a new anti-Ca agent, on left ventricular function in patients with and without angina pectoris.
Insights
Diltiazem hydrochloride impacts left ventricular function differently in patients. It reduces function in those without angina pectoris but improves it in patients with angina pectoris.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Left ventricular function is crucial for cardiovascular health.
- Diltiazem hydrochloride is a calcium channel blocker used in cardiovascular conditions.
Purpose of the Study:
- To investigate the effects of diltiazem hydrochloride on left ventricular function.
- To compare these effects in patients with and without angina pectoris.
Main Methods:
- Intravenous administration of diltiazem hydrochloride (40 mug/Kg).
- Measurement of left ventricular volume and function using an ultrasonic analogue conversion system.
- Inclusion of 12 patients without angina pectoris and 10 patients with angina pectoris.
Main Results:
- In patients without angina pectoris: decreased cardiac index (CI), ejection fraction (EF), and increased end-systolic volume index (ESVI).
- In patients with angina pectoris: a tendency towards increased EF and improved myocardial contractility.
- Both groups showed similar changes in systemic blood pressure, heart rate, and systemic vascular resistance.
Conclusions:
- Diltiazem hydrochloride reduces left ventricular function in patients without angina pectoris.
- Diltiazem hydrochloride improves left ventricular function in patients with angina pectoris.
Abstract:
The effect of diltiazem hydrochloride on left ventricular function has been examined in patients with and without angina pectoris. Left ventricular volume and function were measured by ultrasonic analogue conversion system. In 12 patients without angina pectoris, a fall in systemic blood pressure, a decrease in heart rate, no change in EDVI, an increase in ESVI, decreases in CI, EF, endocardial mean Vcf, normailized mean systolic ejection rate, SWI, and W/min while no change in systemic vascular resistance were observed following the intravenous injections of 40 mug/Kg of the agent. In 10 patients with angina pectoris, decreases in EDVI and ESVI, no change in CI, a tendency of increases in EF, endocardial mean Vcf, and normalized mean systolic ejection rate were observed following the administrations of the same dose. Changes in systemic blood pressure, heart rate, SWI, W/min, and systemic vascular resistance were the same as those in patients without angina pectoris. The results indicate diltiazem-induced reduction in left ventricular function in patients without angina pectoris whereas improvement in left ventricular function in patients with angina pectoris.