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[Linkage studies of a familial spastic paraplegia pedigree from Tibet]
1Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005 P. R. China.
Objective:
To study the location of disease-related gene in a hereditary spastic paraplegia family with autosomal dominant inheritance in Tibet.
Methods:
The AD-HSP family in Tibet was analyzed by linkage studies using 9 highly polymorphic microsatellite DNA markers at three chromosomal regions.
Results:
The maxium Lod- Score of D14S264 was 0.5163(theta=0.05); of D14S75, 2. 1072 (theta=0);+D14S69, 0.2840 (theta=0.10); of D14S266, 0.9311 (theta=0);of D14S66, 0.7991(theta=0);OF GABRB3, 0(theta =0.40);of D15S128, 0(theta=0.40); of D2S2255, 0 (theta=0.40);and of D2S2347,0(theta=0.40).
Conclusion:
In this Tibetian family, the disease-related gene is linked to D14S75 locus of SPG3 region.