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[Genetic polymorphisms of CYP1A1 and susceptibility of lung cancer]
1Research Unit of Molecular Toxicology,Sun Yat-Sen University of Medical Sciences, Guangzhou, Guangdong, 510089 P. R. China. Yilhu@163.net.
Objective:
To assess the possible association between the polymorphisms of CYP1A1 and the susceptibility of lung cancer so as to provide clues for genetic markers of lung cancer.
Methods:
CYP1A1 rare genotypes MspI C and VV were detected with the methods of PCR-RFLP and ASA in a case-control study including 59 cases of lung cancer, 59 hospital controls and 73 healthy controls.
Results:
The frequencies of rare genotypes C and VV of the lung cancer cases were not significantly different from those of the controls, though the frequency of C(25.4%) of the lung cancer cases was higher than that (16.5%) of the controls. However, in the non-smoking group with genotype(C),the risk of lung cancers was 2.43-2.91 times greater than that of the controls. Heterozygote B was overpresented in healthy controls (61.6%),compared to that of lung cancer cases(37.3%), P <0.01,odds ratio 0.37 (95% confidence interval 0.17-0.80).
Conclusion:
Genotype C may be one of the susceptibly genetic markers of lung cancer in the non-smoking population. The risk of lung cancer can be decreased in persons with heterozygote.