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A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
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The clinical pharmacology of brompheniramine in children

F E Simons1, J R Roberts, X Gu

  • 1Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

The Journal of Allergy and Clinical Immunology
|February 9, 1999
PubMed

Insights

Brompheniramine provides prompt and long-lasting H1-blockade in children, supporting its use for allergic rhinitis. Further research may refine pediatric dosing for this antihistamine.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Allergy & Immunology

Background:

  • Brompheniramine is a widely used antihistamine for allergic rhinitis.
  • Clinical pharmacology studies in children are lacking.

Purpose of the Study:

  • To evaluate the onset and duration of action of brompheniramine in children.
  • To test the hypothesis of a prompt and 24-hour effect.

Main Methods:

  • Plasma brompheniramine concentrations were measured using HPLC.
  • Histamine-induced wheals and flares were assessed to determine H1-blockade.
  • Measurements were taken at intervals up to 30 hours post-dose.

Main Results:

  • Peak plasma concentrations were reached at 3.2 hours.
  • Significant reduction in histamine response observed for up to 30 hours.
  • Terminal elimination half-life was 12.4 hours.

Conclusions:

  • A single dose of brompheniramine offers prompt and sustained peripheral H1-blockade in pediatric patients.
  • Current pediatric dosage regimens may require revision based on these findings.
Abstract

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