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Published on: August 25, 2014
Methodological issues in the study of rare exposures and rare outcomes in perinatal epidemiology
1Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
Abstract:
Epidemiologic study of rare exposures and rare outcomes is complicated. For perinatal epidemiology, a prospective cohort study design is preferred for reproductive outcomes with incidences of at least 5%. Case-control studies are generally used to investigate rare outcomes with incidences from 5 per 1000 to less than 1 per 1000. However, obtaining data on large numbers of rare cases can be difficult. The use of nested case-control designs or nested prospective studies may be particularly useful in perinatal epidemiology.
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