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Bilateral eyelid edema: an uncommon presentation of Rosai-Dorfman disease
C R Pelletier1, D R Jordan, M Jabi
1Department of Ophthalmology, Sacre-Coeur Hospital, Montreal, Quebec.
Purpose:
Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare entity with ophthalmic manifestations in 11% of patients. Orbital and eyelid involvement as the presenting features is even more unusual.
Methods:
The authors report the clinical findings of a 41-year-old man with Rosai-Dorfman disease presenting as eyelid edema. Biopsy of the involved tissue was analyzed by light microscopy.
Results:
Histologically the orbicularis muscle contained a patchy infiltrate of lymphocytes, plasma cells, and large pale histiocytes. The histiocytes had lymphocytes within them, a condition referred to as lymphocytophagocytosis.
Conclusions:
Rosai-Dorfman disease is a rare clinical entity that may occasionally manifest with eyelid edema. Biopsy reveals a characteristic histopathologic picture.