Related Experiment Video
Updated: Aug 17, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
Published on: November 3, 2023
[Recurrent epistaxis in children as an indicator of hemostatic disorders]
F J García Callejo1, M M Velert Vila, J Marco Algarra
1Servicio de Otorrinolaringología, Hospital Clínico Universitario, Valencia.
Insights
Severe recurrent nosebleeds in children may indicate underlying coagulation disorders. Specific clinical features help identify children needing hemostasis testing to rule out bleeding conditions.
Area of Science:
- Pediatric Hematology
- Hemostasis and Thrombosis
- Clinical Diagnostics
Context:
- Recurrent epistaxis is common in children, but distinguishing benign cases from those indicative of serious underlying conditions is crucial.
- Primary and secondary hemostasis play vital roles in controlling bleeding, and their dysfunction can manifest as frequent or severe nosebleeds.
Purpose:
- To identify clinical characteristics of recurrent epistaxis in children that correlate with underlying coagulation disorders.
- To evaluate the utility of specific hemostatic tests in diagnosing hemostatic abnormalities in pediatric epistaxis.
Summary:
- This study analyzed 58 children with epistaxis, classifying it as mild or severe based on clinical factors.
- Severe epistaxis cases showed a significantly higher rate of laboratory abnormalities (57.9%) compared to mild cases (10.3%).
- Specific diagnoses included von Willebrand's disease, Bernard-Soulier syndrome, autoimmune thrombocytopenic purpura, and Rendü-Osler-Weber disease in children with severe epistaxis.
Impact:
- The findings provide a clinical framework for identifying children with recurrent epistaxis who require further investigation for hemostatic disorders.
- Early identification and diagnosis of coagulation disorders can lead to timely management and prevent complications.
Objective:
To distinguish which nosebleeds in children hide an underlying coagulation disorder, characteristics of recurrent epistaxis were evaluated correlating the severity with a battery of specific tests on primary and secondary hemostasis.
Patients And Methods:
Epistaxis of fifty-eight children were classified as mild or severe according to frequency, duration, amount of blood lost, proportion of life that nosebleeds have been recurrent and uni- or bilateral bleeding. Epidemiological characteristics were evaluated, as well as hemostatic tests including: platelet count, mean platelet volume, plasmatic fibrinogen level, prothrombine time, activated partial thromboplastin time, thrombin time, bleeding time, von Willebrand factor antigen and ristocetin cofactor, factor VIII coagulant, and platelet aggregation to different agents. The effect of drugs or the presence of tumors was discarded.
Results:
In the group of children with mild epistaxis (n = 39) there were three cases with laboratory abnormalities (10.3%). In severe epistaxis (n = 19) abnormalities were found in eleven cases (57.9%) and specific entities were detected in six of them (three children with von Willebrand's disease, one Bernard-Soulier syndrome, one autoimmune thrombocytopenic purpura and one Rendü-Osler-Weber disease). Epistaxis labeled as mild needed less cauterizations and packings, were more related to seasonal prevalence and self-handling, and poorly influenced iron metabolism.
Conclusions:
The five qualities pointed out on recurrent epistaxis in children allow the identification of who must be thoroughly studied by means of specific tests to rule out any kind of hemostatic disorder.
Related Concept Videos
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Esophageal Varices-I: Introduction
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology

