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Related Experiment Videos

[Pituitary adenylate cyclase-activating polypeptide]

B J Gonzalez1, M Basille, D Vaudry

  • 1Institut Fédératif de Recherches Multidisciplinaire sur les Peptides (IFRMP n. 23), INSERM U413, UA CNRS, Université de Rouen, Mont-Saint-Aignan, France.

Annales D'Endocrinologie
|February 9, 1999
PubMed
Summary

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a conserved peptide hormone with diverse roles in the nervous and endocrine systems. Its various forms and receptors suggest broad physiological importance and therapeutic potential.

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Area of Science:

  • Endocrinology and Neurobiology
  • Molecular and Cellular Biology
  • Evolutionary Biology

Context:

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) identified in sheep hypothalamus.
  • PACAP precursor yields PACAP38, PACAP27, and PACAP-related peptide.
  • PACAP structure conserved across vertebrates, indicating vital functions.

Purpose:

  • To review the diverse biological activities of PACAP.
  • To explore PACAP's roles as a hormone, neurohormone, neurotransmitter, and trophic factor.
  • To describe PACAP receptor subtypes and their signaling pathways.

Summary:

  • PACAP regulates insulin, glucagon, steroidogenesis, and pituitary hormone secretion.
  • PACAP exhibits smooth muscle relaxant effects in blood vessels, lungs, and gut.

Related Experiment Videos

  • PACAP influences neuronal activity, gene expression, and developmental processes.
  • PACAP mediates effects via PAC1, VPAC1, and VPAC2 receptors with varying affinities.

    • Impact:

    • PACAP's neurotrophic and neuroprotective actions are significant for development.
    • PACAP's bronchodilator and vasorelaxant properties offer therapeutic avenues.
    • PACAP receptor interactions highlight potential for novel drug development.