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The murine Cd48 gene: allelic polymorphism in the IgV-like region
J G Cabrero1, G J Freeman, H Reiser
1Unidad de Investigacion, Fundación Jiménez Diaz, Madrid, Spain.
Abstract:
The murine CD48 molecule is a member of the immunoglobulin superfamily which regulates the activation of T lymphocytes. prior cloning experiments using mRNA from two different mouse strains had yielded discrepant sequences within the IgV-like domain of murine CD48. To resolve this issue, we have directly sequenced genomic DNA of 10 laboratory strains and two inbred strains of wild origin. The results of our analysis reveal an allelic polymorphism within the IgV-like domain of murine CD48.
