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The management of unexplained infertility
1Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Amman, Jordan. fhmzayed@just.edu.jo
Obstetrical & Gynecological Survey
|February 9, 1999
Summary
Unexplained infertility management involves evaluating treatments like clomiphene citrate, which doubles pregnancy rates. Assisted reproductive techniques are considered if initial treatments fail.
Area of Science:
- Reproductive Endocrinology
- Infertility Management
Background:
- Unexplained infertility (UI) affects 6-60% of couples, diagnosed after excluding other causes.
- Standard investigations often reveal no identifiable abnormalities in UI cases.
Purpose of the Study:
- To review literature on managing unexplained infertility.
- To guide healthcare providers in appropriate workup and treatment planning for UI.
Main Methods:
- Literature review of published data on UI management.
- Analysis of treatment efficacy for various interventions.
Main Results:
- Danazol and bromocriptine show no benefit for UI.
- Clomiphene citrate can double spontaneous pregnancy rates.
- Human menopausal gonadotropin (hMG) yields 2-26% pregnancy rates per cycle, lower than IVF/GIFT.
Conclusions:
- A rational plan includes up to four cycles of clomiphene citrate with or without intrauterine insemination (IUI).
- Superovulation with hMG and IUI/SIUI is the next step.
- Assisted reproductive techniques (ART) are considered if other methods fail.