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Postnatal changes in locomotor movements after labyrinthectomy in rats
1Department of Otolaryngology, Otsu Red Cross Hospital, Nagara, Japan. jnyak@skyblue.ocn.nejp
Abstract:
The influence of unilateral or bilateral labyrinthectomy on the postnatal development of locomotor movements was studied in newborn rats. Locomotor movements of the rats were measured on the surface of a digitizer table by attaching a miniature resonance coil to the abdomen of the rat. Labyrinthectomy was performed in rats on postnatal day (PND) 11. From PND 10 to PND 14, the total distance and mean velocity of locomotor movements were significantly lower in the labyrinthectomized rats than in the control rats. From PND 17 to PND 20, the total distance and mean velocity of the locomotor movements of the unilateral labyrinthectomized rats gradually recovered to an almost normal level. However, those of the bilateral labyrinthectomized rats remained at insufficient levels even at PND 20.