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Related Experiment Videos

Differences between asthma exacerbations and poor asthma control

H Reddel1, S Ware, G Marks

  • 1Institute of Respiratory Medicine at Royal Prince Alfred Hospital and the University of Sydney, Camperdown, NSW, Australia. hkr@mail.med.usyd.edu.au

Lancet (London, England)
|February 9, 1999
PubMed
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Asthma exacerbations show different peak expiratory flow (PEF) patterns than poorly controlled asthma, even when diurnal variability is similar. This suggests distinct beta2-adrenoceptor function during exacerbations, impacting lung function assessment.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Increased peak expiratory flow (PEF) variation indicates poorly controlled asthma.
  • Diurnal PEF variability is recommended for assessing asthma severity and exacerbations.

Purpose of the Study:

  • To determine if asthma exacerbations exhibit the same PEF characteristics as poorly controlled asthma.

Main Methods:

  • Examined electronic PEF records from 43 patients with poorly controlled asthma.
  • Compared diurnal PEF variability during exacerbations, poor control, and stable asthma phases.

Main Results:

  • Diurnal PEF variability was 21.3% in poor control, improving to 5.3% with treatment.
  • During exacerbations (95% linked to respiratory infections), variability was 7.7%, not significantly higher than stable asthma (5.4%).

Related Experiment Videos

  • PEF data indicated impaired beta2-agonist response during exacerbations, but not during poor control.

    • Conclusions:

    • Asthma patients are susceptible to exacerbations during infections, even with controlled asthma.
    • Diurnal PEF variability may not detect significant lung function changes during exacerbations.
    • PEF variation differs between exacerbations and poor control, suggesting altered beta2-adrenoceptor function.