Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colorectal cancer

R Midgley1, D Kerr

  • 1CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK.

Lancet (London, England)
|February 9, 1999
PubMed
Summary
This summary is machine-generated.

Colorectal cancer treatments like chemotherapy and radiotherapy improve survival and quality of life. Advances in gene therapy and multidisciplinary care offer new hope for patients with this common malignancy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial.

ESMO open·2022
Same author

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial.

NPJ digital medicine·2021
Same author

ESMO's new strategic plan: our society's road to the future of oncology.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Predicting changes in the status of patient-reported outcome measures after Birmingham Hip Resurfacing: an observational cohort study with a median follow-up of ten years.

The bone & joint journal·2019
Same author

The outcome and survival of metal-on-metal hip resurfacing in patients aged less than 50 years: a prospective observational cohort study with minimum ten-year follow-up.

The bone & joint journal·2019
Same author

Occupational exposure to methoxyflurane administered for procedural sedation: an observational study of 40 exposures.

British journal of anaesthesia·2018
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Colorectal cancer is a significant cause of mortality globally, with high incidence in Europe and the USA.
  • Established treatments include chemotherapy for adjuvant and advanced stages, and radiotherapy for rectal cancer to reduce recurrence and palliate symptoms.

Purpose of the Study:

  • To review current treatment modalities for colorectal cancer.
  • To highlight the impact of evolving understanding of colorectal carcinogenesis on therapeutic strategies.
  • To emphasize the importance of specialized surgical care and a multidisciplinary approach.

Main Methods:

  • Review of published clinical trials and established treatment guidelines.
  • Discussion of advancements in understanding tumor development and gene therapy.

Related Experiment Videos

  • Emphasis on the role of specialized surgical care and multidisciplinary teams.

    • Main Results:

    • Chemotherapy offers a survival benefit in Dukes C colon cancer and improves outcomes in advanced colorectal cancer.
    • Radiotherapy effectively reduces local recurrence in rectal cancer and palliates symptoms in locally advanced disease.
    • Gene therapy presents innovative approaches based on understanding cancer genetics.

    Conclusions:

    • Optimal outcomes for colorectal cancer patients are achieved through a combination of chemotherapy, radiotherapy, and potentially gene therapy.
    • Surgical site specialization and a multidisciplinary approach are crucial for effective patient management and improved survival rates.