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Feverfew as a preventive treatment for migraine: a systematic review
B K Vogler1, M H Pittler, E Ernst
1Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, UK.
Background:
Feverfew is a popular herbal remedy advocated for the prevention of migraine.
Aim:
The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention.
Data Sources:
Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998).
Study Selection:
Only randomized, placebo-controlled, double-blind trials were included.
Data Extraction:
All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score.
Main Results:
Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist.
Conclusion:
The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt.