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[Meningitis due to Salmonella in the neonatal period]

M E Vázquez-López1, R Pego, C Somoza

  • 1Servicio de Pediatría, Hospital Xeral-Calde, Lugo, España.

Revista De Neurologia
|February 10, 1999
PubMed
Abstract

Insights

Salmonella meningitis is a rare but serious infection in infants, often linked to gastrointestinal issues. Prompt antibiotic treatment, like cefotaxime, is crucial for a full recovery without long-term effects.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Salmonella typically causes gastrointestinal illness but can lead to invasive infections like meningitis, particularly in neonates.
  • Salmonella meningitis, though uncommon, carries significant morbidity and mortality, primarily affecting infants under four months.
  • This condition often presents with or follows gastroenteritis and has a rapid clinical progression.

Observation:

  • A 17-day-old neonate presented with irritability, diarrhea, and persistent fever unresponsive to antipyretics.
  • Lumbar puncture revealed cloudy cerebrospinal fluid (CSF), indicative of bacterial meningitis.
  • CSF culture identified Salmonella, exhibiting resistance to ampicillin but sensitivity to cefotaxime.

Findings:

  • The infant received a 21-day course of intravenous ampicillin and cefotaxime.
  • The patient demonstrated excellent clinical recovery.
  • Eight-month follow-up showed normal psychomotor, physical, and weight development, with no sequelae.

Implications:

  • Early diagnosis and appropriate antibiotic therapy are critical for favorable outcomes in Salmonella meningitis.
  • This case underscores the importance of considering Salmonella in the differential diagnosis of neonatal meningitis.
  • Effective treatment can prevent long-term complications in affected infants.

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