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Updated: Aug 8, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
[Holmes-Adie syndrome. Clinical case]
A C Rodríguez-Barrionuevo1, A Herrero-Hernández, L Vázquez-Martín
1Servicio de Neuropediatría, Hospital Materno-Infantil Carlos Haya, Málaga, España.
Introduction:
The Adie tonic pupil is an intrinsic, isolated and benign ophthalmoplegia producing defective accommodation and anisocoria. The affectation is unilateral in the 90% of cases and can appear at any age. If associated to patellar tendinous reflexes abolition, constitutes Holmes-Adie syndrome.
Clinical Case:
We present a 6 years old girl. She suffered a right temporal trauma with cephalea and vomiting for a few hours. After two months, she presented right mydriasis. There were no familiar antecedents. After a year evolution, she has not presented clinical changes.
Conclusion:
We comment the process's physiopathology.
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