[The protective action of alpha-tocopherol on kidney function and lipid peroxidation in acute hemic hypoxia]

As shown in experiments on 54 noninbred white male rats, activation of lipid peroxidation in renal cortical substance contributes to impairment of renal function in acute hemic hypoxia. Administration of alpha-tocopherol promoted stimulation of renal protection: reduced the degree of proteinuria, sodium excretion, enhanced proximal reabsorption of osmotically active substances and sodium, glomerular filtration. This was accompanied with increased activity of superoxide dismutase and lowering of malonic dialdehyde concentration in renal cortical substance.