Related Experiment Videos
Autoimmune panleukopenia
Abstract:
A patient with episodic panleukopenia involving neutrophilic granulocytes, monocytes and lymphocytes had recurrent bacterial infections and a circulating cytotoxin that injured primitive myeloid cells as well as differentiated granulocytes and mononuclear cells. The cytotoxin was an immunoglobulin with activity against mouse, as well as human, myeloid stem cells. Clinical remission during cyclophosphamide therapy was associated with disappearance of the circulating leukocytotoxin. Serum from a period of active disease was cytotoxic for the patient's own lymphocytes obtained during clinical remission. Absorption of cytotoxic serum with granulocytes removed activity against both granulocytes and lymphocytes. These studies suggest an autoimmune disease in man characterized by episodic granulocytopenia, monocytopenia and lymphocytopenia due to humoral antibody against non-HLA antigens shared by several hematopoietic cell lines.
Insights
This study identifies an autoimmune disorder causing low white blood cell counts (panleukopenia) due to a specific antibody. Treatment led to remission by eliminating this leukocytotoxin.
Area of Science:
- Immunology
- Hematology
- Autoimmune Diseases
Background:
- A patient presented with recurrent bacterial infections and episodic panleukopenia affecting granulocytes, monocytes, and lymphocytes.
- A circulating cytotoxin was identified, damaging both primitive myeloid stem cells and mature myeloid and mononuclear cells.