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Possible dihydroepiandrosterone-induced mania

J S Markowitz1, W H Carson, C W Jackson

  • 1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA.

Biological Psychiatry
|February 10, 1999
PubMed
Summary
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This case study highlights a potential link between dehydroepiandrosterone (DHEA) supplements and manic episodes. An older man with no prior history of bipolar disorder developed mania after taking DHEA, underscoring the need for caution.

Area of Science:

  • Endocrinology
  • Neuropsychiatry

Background:

  • Dehydroepiandrosterone (DHEA) is a prevalent endogenous steroid with diverse biochemical functions.
  • Widespread availability as an over-the-counter supplement has increased public DHEA consumption.
  • Limited understanding exists regarding the adverse effects of DHEA, particularly on mental health.

Observation:

  • A case report details an older male patient admitted for acute mania.
  • The patient had no personal or familial history of bipolar disorder.
  • DHEA supplementation was initiated 6 months prior to admission, with daily doses of 200-300 mg.

Findings:

  • The patient's manic symptoms appeared to be associated with DHEA use.
  • Treatment with valproic acid resulted in significant improvement.

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  • The patient was discharged after a 7-day hospitalization.

    • Implications:

    • This case suggests a potential for DHEA to induce manic symptoms in susceptible individuals.
    • Further research is warranted to explore the neuropsychiatric effects of DHEA supplementation.
    • Clinicians should consider DHEA use when evaluating patients presenting with new-onset mania.